Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior

Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior

Summary: The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid (eCB) system have been implicated in reward seeking. However, the preci...

Full description

Bibliographic Details
Main Authors: Ainhoa Bilbao, Daniela Neuhofer, Marja Sepers, Shou-peng Wei, Manuela Eisenhardt, Sarah Hertle, Olivier Lassalle, Almudena Ramos-Uriarte, Nagore Puente, Raissa Lerner, Aurore Thomazeau, Pedro Grandes, Beat Lutz, Olivier J. Manzoni, Rainer Spanagel
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220301358

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220301358

Similar Items