Long-Term Paracetamol Treatment Impairs Cognitive Function and Brain-Derived Neurotrophic Factor in Adult Rat Brain

Long-Term Paracetamol Treatment Impairs Cognitive Function and Brain-Derived Neurotrophic Factor in Adult Rat Brain

Paracetamol (acetaminophen, APAP) is known as a safe pain reliever; however, its negative effects on the central nervous system have gradually been reported. We examined alterations in learning and memory, and brain-derived neurotrophic factor (BDNF) expression in the frontal cortex and hippocampus...

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Bibliographic Details
Main Authors: Laddawan Lalert, Nutnicha Tantarungsee, Tipthanan Chotipinit, Wilawan Ji-au, Anan Srikiatkhachorn, Supang Maneesri-le Grand
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Scientia Pharmaceutica
Subjects:
paracetamol
novel object recognition
Morris water maze
brain-derived neurotrophic factor
frontal cortex
hippocampus
Online Access:https://www.mdpi.com/2218-0532/91/1/11

Internet

https://www.mdpi.com/2218-0532/91/1/11

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