GPR120/FFAR4 stimulation attenuates airway remodeling and suppresses IL-4- and IL-13-induced airway epithelial injury via inhibition of STAT6 and Akt

GPR120/FFAR4 stimulation attenuates airway remodeling and suppresses IL-4- and IL-13-induced airway epithelial injury via inhibition of STAT6 and Akt

Background: Airway remodeling is associated with severity and treatment insensitivity in asthma. This study aimed to investigate the effects of G protein-coupled receptor 120 (GPR120) stimulation on alleviating allergic inflammation and remodeling of airway epithelium. Research design and methods: O...

Full description

Bibliographic Details
Main Authors: Aekkacha Moonwiriyakit, Chantapol Yimnual, Rattikarn Noitem, Sasiwimol Dinsuwannakol, Jenjira Sontikun, Suchada Kaewin, Nichakorn Worakajit, Virawudh Soontornniyomkij, Chatchai Muanprasat
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Asthma
GPR120
FFAR4
Airway remodeling
IL-13
STAT6
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222301572X

Internet

http://www.sciencedirect.com/science/article/pii/S075333222301572X

Similar Items