Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment

Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment

Abstract Adolescent binge drinking represents a major public health challenge and can lead to persistent neurological and mental conditions, but the underlying pathogenic mechanisms remain poorly understood. Using a mouse model of adolescent binge ethanol treatment (ABET), we found that this treatme...

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Bibliographic Details
Main Authors: James Rice, Laurence Coutellier, Jeffrey L. Weiner, Chen Gu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Acta Neuropathologica Communications
Subjects:
Adolescent binge ethanol treatment (ABET)
Anxiety
Gray matter myelin
Hippocampus
Medial prefrontal cortex (mPFC)
Parvalbumin-positive (PV+) GABAergic interneuron
Online Access:http://link.springer.com/article/10.1186/s40478-019-0829-9

Internet

http://link.springer.com/article/10.1186/s40478-019-0829-9

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