Structure and Characterization of a Covalent Inhibitor of Src Kinase

Structure and Characterization of a Covalent Inhibitor of Src Kinase

Unregulated Src activity promotes malignant processes in cancer, but no Src-directed targeted therapies are used clinically, possibly because early Src inhibitors produce off-target effects leading to toxicity. Improved selective Src inhibitors may enable Src-directed therapies. Previously, we repor...

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Bibliographic Details
Main Authors: Deepak Gurbani, Guangyan Du, Nathaniel J. Henning, Suman Rao, Asim K. Bera, Tinghu Zhang, Nathanael S. Gray, Kenneth D. Westover
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
src kinase
cancer
dasatinib
selectivity
irreversible inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00081/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00081/full

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