GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils

GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils

The fate of infiltrating neutrophils in inflamed joints determines the development of acute gouty arthritis (AGA). GPR105 highly expressed in human neutrophils is sensitive to monosodium urate crystals (MSU); nevertheless, the roles of GPR105 in AGA remain unclear. Here, we show that GPR105 is signi...

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Bibliographic Details
Main Authors: Chunxiao Liu, Mengze Zhou, Wenjiao Jiang, Shumin Ye, Sheng Tian, Cheng Jiang, Kun Hao, Huanqiu Li, Qinghua Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
GPR105
NETosis
apoptosis
acute gouty arthritis
cAMP-PKA
lobetyolin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.870183/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.870183/full

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