Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole

Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole

Surfactants have been widely used as effective additives to increase the solubility and dissolution rates of amorphous solid dispersions (ASDs). However, they may also generate adverse effects on the physical stability of ASDs. In this study, we systematically investigated the impacts of poloxamer,...

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Bibliographic Details
Main Authors: Jie Zhang, Ziqing Yang, Liquan Luo, Kang Li, Taotao Zi, Junjie Ren, Lei Pan, Ziyue Wang, Zihao Wang, Minzhuo Liu, Zhihong Zeng
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
poloxamer
nucleation
crystallization
polymorphs
clotrimazole
Online Access:https://www.mdpi.com/1999-4923/15/8/2164

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https://www.mdpi.com/1999-4923/15/8/2164

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