High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos

Abstract Three-dimensional (3D) organoid cultures are flexible systems to interrogate cellular growth, morphology, multicellular spatial architecture, and cellular interactions in response to treatment. However, computational methods for analysis of 3D organoids with sufficiently high-throughput and...

Full description

Bibliographic Details
Main Authors: Patience Mukashyaka, Pooja Kumar, David J. Mellert, Shadae Nicholas, Javad Noorbakhsh, Mattia Brugiolo, Elise T. Courtois, Olga Anczukow, Edison T. Liu, Jeffrey H. Chuang
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44162-6