Modeling the effect of environmental cytokines, nutrient conditions and hypoxia on CD4+ T cell differentiation

Upon antigen stimulation and co-stimulation, CD4+ T lymphocytes produce soluble factors that promote the activity of other immune cells against pathogens or modified tissues; this task must be performed in presence of a variety of environmental cytokines, nutrient, and oxygen conditions, which neces...

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Bibliographic Details
Main Authors: David Martínez-Méndez, Leonor Huerta, Carlos Villarreal
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.962175/full