Nucleotide-amino acid π-stacking interactions initiate photo cross-linking in RNA-protein complexes

Nucleotide-amino acid π-stacking interactions initiate photo cross-linking in RNA-protein complexes

Although UV-induced cross-linking is a widely used method to study RNA-protein complexes, the cross-linking reactions are poorly understood. Here, the authors show that π-stacking interactions between nucleobases and aromatic amino acids play a key role in the cross-linking process.

Bibliographic Details
Main Authors: Anna Knörlein, Chris P. Sarnowski, Tebbe de Vries, Moritz Stoltz, Michael Götze, Ruedi Aebersold, Frédéric H.-T. Allain, Alexander Leitner, Jonathan Hall
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30284-w

Internet

https://doi.org/10.1038/s41467-022-30284-w

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