Ablation of T cell–associated PD-1H enhances functionality and promotes adoptive immunotherapy

Ablation of T cell–associated PD-1H enhances functionality and promotes adoptive immunotherapy

Programmed death-1 homolog (PD-1H) is a coinhibitory molecule that negatively regulates T cell–mediated immune responses. In this study, we determined whether ablation of T cell–associated PD-1H could enhance adoptive T cell therapy in experimental tumor models. The expression of PD-1H is upregulate...

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Bibliographic Details
Main Authors: Li Hu, Ling Chen, Zexiu Xiao, Xu Zheng, Yuangui Chen, Na Xian, Christina Cho, Liqun Luo, Gangxiong Huang, Lieping Chen
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-01-01
Series:JCI Insight
Subjects:
Immunology
Therapeutics
Online Access:https://doi.org/10.1172/jci.insight.148247

Internet

https://doi.org/10.1172/jci.insight.148247

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