The Human ApoE4 Variant Reduces Functional Recovery and Neuronal Sprouting After Incomplete Spinal Cord Injury in Male Mice

The Human ApoE4 Variant Reduces Functional Recovery and Neuronal Sprouting After Incomplete Spinal Cord Injury in Male Mice

Spinal cord injury (SCI) is a devastating form of neurotrauma. Patients who carry one or two apolipoprotein E (ApoE)4 alleles show worse functional outcomes and longer hospital stays after SCI, but the cellular and molecular underpinnings for this genetic link remain poorly understood. Thus, there i...

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Bibliographic Details
Main Authors: Carlos A. Toro, Jens Hansen, Mustafa M. Siddiq, Kaitlin Johnson, Wei Zhao, Daniella Azulai, Dibash K. Das, William Bauman, Robert Sebra, Dongming Cai, Ravi Iyengar, Christopher P. Cardozo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ApoE
spinal cord injury
functional recovery after SCI
sprouting
neurite outgrowth
glial activation
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.626192/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.626192/full

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