Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8+ T cells

Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8+ T cells

Introduction and methodsIn this present work, coronavirus subfamilies and SARS-CoV-2 Variants of Concern (VOCs) were investigated for the presence of MHC-I immunodominant viral peptides using in silico and in vitro tools.ResultsIn our results, HLA-A*02 haplotype showed the highest number of immunodo...

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Bibliographic Details
Main Authors: Ágata Lopes-Ribeiro, Patrícia de Melo Oliveira, Henrique Morais Retes, Edel Figueiredo Barbosa-Stancioli, Flávio Guimarães da Fonseca, Moriya Tsuji, Jordana Grazziela Alves Coelho-dos-Reis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cells
SARS-CoV-2
HLA-A2
peptide microarray
immunoinformatics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229712/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229712/full

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