Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

Emerging evidence has indicated that the perturbed expression of homocysteine (Hcy) may induce mitochondrial dysfunction and disturb bone metabolism. Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) are two critical sensors that regulate mitochondrial biogenesis and have been recognized as...

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Bibliographic Details
Main Authors: Ching-Hou Ma, Yen Chun Chiua, Chin-Hsien Wu, I.-Ming Jou, Yuan-Kun Tu, Ching-Hsia Hung, Pei-Ling Hsieh, Kun-Ling Tsai
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
SIRT1
AMPK
Osteoarthritis
Hyperhomocysteinemia
Chondrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718300375

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http://www.sciencedirect.com/science/article/pii/S2213231718300375

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