The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-mesenchymal transition (EMT) factor SNAI1 (SNAIL) p...

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Bibliographic Details
Main Authors: Juli J. Unternaehrer, Rui Zhao, Kitai Kim, Marcella Cesana, John T. Powers, Sutheera Ratanasirintrawoot, Tamer Onder, Tsukasa Shibue, Robert A. Weinberg, George Q. Daley
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114002938

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http://www.sciencedirect.com/science/article/pii/S2213671114002938

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