Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
Salt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathw...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Jezik: | English |
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Nature Portfolio
2020-08-01
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| Serija: | Nature Communications |
| Online dostop: | https://doi.org/10.1038/s41467-020-18184-3 |
| _version_ | 1831572511934906368 |
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| author | Rhys D. R. Evans Marilina Antonelou Sanchutha Sathiananthamoorthy Marilena Rega Scott Henderson Lourdes Ceron-Gutierrez Gabriela Barcenas-Morales Christoph A. Müller Rainer Doffinger Stephen B. Walsh Alan D. Salama |
| author_facet | Rhys D. R. Evans Marilina Antonelou Sanchutha Sathiananthamoorthy Marilena Rega Scott Henderson Lourdes Ceron-Gutierrez Gabriela Barcenas-Morales Christoph A. Müller Rainer Doffinger Stephen B. Walsh Alan D. Salama |
| author_sort | Rhys D. R. Evans |
| collection | DOAJ |
| description | Salt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathways are intact and can be reinvigorated by exogenous salt. |
| first_indexed | 2024-12-17T13:28:41Z |
| format | Article |
| id | doaj.art-2cec9c8266184037b9f92780094ab2b6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T13:28:41Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2cec9c8266184037b9f92780094ab2b62022-12-21T21:46:39ZengNature PortfolioNature Communications2041-17232020-08-0111111910.1038/s41467-020-18184-3Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responsesRhys D. R. Evans0Marilina Antonelou1Sanchutha Sathiananthamoorthy2Marilena Rega3Scott Henderson4Lourdes Ceron-Gutierrez5Gabriela Barcenas-Morales6Christoph A. Müller7Rainer Doffinger8Stephen B. Walsh9Alan D. Salama10Department of Renal Medicine, University College London, Royal Free HospitalDepartment of Renal Medicine, University College London, Royal Free HospitalDepartment of Renal Medicine, University College London, Royal Free HospitalInstitute of Nuclear Medicine, University College London, University College London HospitalDepartment of Renal Medicine, University College London, Royal Free HospitalDepartment of Clinical Biochemistry and Immunology, Addenbrookes’s HospitalLaboratorio de Inmunologia, FES-CuautitlanDepartment of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Clinical Biochemistry and Immunology, Addenbrookes’s HospitalDepartment of Renal Medicine, University College London, Royal Free HospitalDepartment of Renal Medicine, University College London, Royal Free HospitalSalt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathways are intact and can be reinvigorated by exogenous salt.https://doi.org/10.1038/s41467-020-18184-3 |
| spellingShingle | Rhys D. R. Evans Marilina Antonelou Sanchutha Sathiananthamoorthy Marilena Rega Scott Henderson Lourdes Ceron-Gutierrez Gabriela Barcenas-Morales Christoph A. Müller Rainer Doffinger Stephen B. Walsh Alan D. Salama Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses Nature Communications |
| title | Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses |
| title_full | Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses |
| title_fullStr | Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses |
| title_full_unstemmed | Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses |
| title_short | Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses |
| title_sort | inherited salt losing tubulopathies are associated with immunodeficiency due to impaired il 17 responses |
| url | https://doi.org/10.1038/s41467-020-18184-3 |
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