Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses

Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses

Salt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathw...

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Bibliographic Details
Main Authors: Rhys D. R. Evans, Marilina Antonelou, Sanchutha Sathiananthamoorthy, Marilena Rega, Scott Henderson, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, Christoph A. Müller, Rainer Doffinger, Stephen B. Walsh, Alan D. Salama
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18184-3

Internet

https://doi.org/10.1038/s41467-020-18184-3

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