Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression

Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression

Abstract PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not expressed in normal prostate tissue cells. The specific expression of prostate-specific antigen (PSA) is found to be related with the conditional transcriptional regulat...

Full description

Bibliographic Details
Main Authors: Yi Yang, Hongbing Mei, Xiaohong Han, Xintao Zhang, Jianli Cheng, Zhongfu Zhang, Han Wang, Haixia Xu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cellular & Molecular Biology Letters
Subjects:
CRISPR-dCas9-KRAB
Prostate cancer
PSA
Gene therapy
Online Access:https://doi.org/10.1186/s11658-023-00508-y

Internet

https://doi.org/10.1186/s11658-023-00508-y

Similar Items