Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin

Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin

Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on th...

Full description

Bibliographic Details
Main Authors: Chunyun Pu, Shaorong Tian, Sanxiu He, Weihong Chen, Yuanyuan He, Hongyan Ren, Jing Zhu, Jun Tang, Xiaolan Huang, Ying Xiang, Yixiao Fu, Tingxiu Xiang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-07-01
Series:Genes and Diseases
Subjects:
Cancer
Chronic unpredictability mild stress
CpG methylation
Depression
Hypocretin
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220301501

Internet

http://www.sciencedirect.com/science/article/pii/S2352304220301501

Similar Items