Impact of TR<sub>34</sub>/L98H, TR<sub>46</sub>/Y121F/T289A and TR<sub>53</sub> Alterations in Azole-Resistant <i>Aspergillus fumigatus</i> on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

Impact of TR<sub>34</sub>/L98H, TR<sub>46</sub>/Y121F/T289A and TR<sub>53</sub> Alterations in Azole-Resistant <i>Aspergillus fumigatus</i> on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis. Azole resistance has emerged as a matter of concern but little is known about sterols b...

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Bibliographic Details
Main Authors: Rose-Anne Lavergne, Marjorie Albassier, Jean-Benoît Hardouin, Carlos Alvarez-Moreno, Fabrice Pagniez, Florent Morio, Patrice Le Pape, Isabelle Ourliac-Garnier
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Microorganisms
Subjects:
<i>Aspergillus fumigatus</i>
sterol
ergosterol
azole-resistance
tandem repeat
Online Access:https://www.mdpi.com/2076-2607/10/1/104

Internet

https://www.mdpi.com/2076-2607/10/1/104

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