Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

Abstract Background Four-octyl itaconate (OI), the itaconate’s cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective function of OI in hydrogen peroxide (H2O2)-treated neuronal cells. Methods SH...

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Bibliographic Details
Main Authors: Hua Liu, Yu Feng, Min Xu, Jian Yang, Zhichun Wang, Guangfu Di
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
Four-octyl itaconate
Keap1-Nrf2 signaling
Neuronal cells
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12964-018-0294-2

Internet

http://link.springer.com/article/10.1186/s12964-018-0294-2

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