Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host Responses in K18-hACE2 Mice

Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host Responses in K18-hACE2 Mice

ABSTRACT Several models were developed to study the pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and therapeutics. Since wild-type mice are naturally resistant to infection by ancestral SARS-CoV-2 strains, several transgeni...

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Bibliographic Details
Main Authors: Côme J. Thieulent, Wellesley Dittmar, Udeni B. R. Balasuriya, Nicholas A. Crossland, Xue Wen, Juergen A. Richt, Mariano Carossino
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mSphere
Subjects:
ACE2-expressing mice
COVID-19
K18-hACE2 mice
MA10
mouse-adapted virus
respiratory infection
Online Access:https://journals.asm.org/doi/10.1128/msphere.00558-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00558-22

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