Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis

Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis

Background: Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand the characteristic immunopathology of tuberculosis. We performed targeted metabolomic analyses in a large cohort of patients with tuberculous meningitis (TBM), the...

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Bibliographic Details
Main Authors: Edwin Ardiansyah, Julian Avila-Pacheco, Le Thanh Hoang Nhat, Sofiati Dian, Dao Nguyen Vinh, Hoang Thanh Hai, Kevin Bullock, Bachti Alisjahbana, Mihai G Netea, Riwanti Estiasari, Trinh Thi Bich Tram, Joseph Donovan, Dorothee Heemskerk, Tran Thi Hong Chau, Nguyen Duc Bang, Ahmad Rizal Ganiem, Rovina Ruslami, Valerie ACM Koeken, Raph L Hamers, Darma Imran, Kartika Maharani, Vinod Kumar, Clary B Clish, Reinout van Crevel, Guy Thwaites, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
tuberculous meningitis
cerebrospinal fluid
plasma
metabolomics
survival
central nervous system
Online Access:https://elifesciences.org/articles/85307

Internet

https://elifesciences.org/articles/85307

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