Novel mutations in genes of the IL-12/IFN-γ axis cause susceptibility to tuberculosis

Novel mutations in genes of the IL-12/IFN-γ axis cause susceptibility to tuberculosis

Background: The IL-12/23/ISG15-IFN-γ pathway is the main immunological pathway for controlling intra-macrophagic microorganisms such as Mycobacteria, Salmonella, and Leishmania spp. Consequently, upon mutations in genes of the IL-12/23/ISG15-IFN-γ pathway cause increased susceptibility to intra-macr...

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Bibliographic Details
Main Authors: Sajjad Ahmad, Jawad Ahmed, Eman H. Khalifa, Farhad Ali Khattak, Anwar Sheed khan, Syed Umar Farooq, Sannaa M.A. Osman, Magdi M. Salih, Nadeem Ullah, Taj Ali Khan
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Infection and Public Health
Subjects:
TB
PBMCs
IL-12Rβ1
NEMO
CYBB
IFN-γ
Online Access:http://www.sciencedirect.com/science/article/pii/S1876034123002101

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http://www.sciencedirect.com/science/article/pii/S1876034123002101

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