Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse.

Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse.

Healing after acute myocardial infarction (AMI) is characterized by an intense inflammatory response and increased Interleukin-1 (IL-1) tissue activity. Genetically engineered mice lacking the IL-1 receptor (IL-1R1-/-, not responsive to IL-1) or the IL-1 receptor antagonist (IL-1Ra, enhanced respons...

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Bibliographic Details
Main Authors: Antonio Abbate, Fadi N Salloum, Benjamin W Van Tassell, Elena Vecile, Stefano Toldo, Ignacio Seropian, Eleonora Mezzaroma, Aldo Dobrina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3225370?pdf=render

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http://europepmc.org/articles/PMC3225370?pdf=render

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