Vaccine induced thrombotic thrombocytopenia: development and reactivity of anti-platelet factor 4 antibodies and immune pathogenic mechanisms

Vaccine induced thrombotic thrombocytopenia: development and reactivity of anti-platelet factor 4 antibodies and immune pathogenic mechanisms

In ultrarare cases, patients vaccinated with DNA adenovirus vector vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), develop a vaccine-induced immune thrombotic thrombocytopenia (VITT), with a high incidence of fatal cases. The causative agent is the development of platel...

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Bibliographic Details
Main Authors: Jean Amiral, Elodie Legros, Marion Vivant, Delphine Rossi, Gwenaëlle Renaud
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2022-08-01
Series:Exploration of Immunology
Subjects:
thrombosis
thrombocytopenia
severe acute respiratory syndrome coronavirus-2
adenovirus vector vaccines
platelet factor 4
autoantibodies
vaccine-induced immune thrombotic thrombocytopenia
Online Access:https://www.explorationpub.com/Journals/ei/Article/100371

Internet

https://www.explorationpub.com/Journals/ei/Article/100371

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