Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors

Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors

Delineating the specific role of Polycomb Repressive Complex 2 (PRC2) in various cancer systems is desirable as inhibitors for EZH2 inhibitors are approved for some cancers. Here the authors show haplo- and full-insufficiency of EZH2 drive divergent phenotypes in lung cancer. 3D tumoroids recapitula...

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Bibliographic Details
Main Authors: Fan Chen, Aria L. Byrd, Jinpeng Liu, Robert M. Flight, Tanner J. DuCote, Kassandra J. Naughton, Xiulong Song, Abigail R. Edgin, Alexsandr Lukyanchuk, Danielle T. Dixon, Christian M. Gosser, Dave-Preston Esoe, Rani D. Jayswal, Stuart H. Orkin, Hunter N. B. Moseley, Chi Wang, Christine Fillmore Brainson
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-35784-x

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https://doi.org/10.1038/s41467-023-35784-x

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