Mechanism of Allosteric Modulation of the Cys-loop Receptors

Mechanism of Allosteric Modulation of the Cys-loop Receptors

The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling neuronal excitability, and brain function. These receptors are allosteric proteins, in that binding of a neurotransmitter to its binding site...

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Bibliographic Details
Main Authors: Paul Whiteaker, Yao Huang, Yongchang Chang
Format: Article
Language:English
Published: MDPI AG 2010-08-01
Series:Pharmaceuticals
Subjects:
cys-loop receptors
ligand-gated ion channels
allosteric modulator
Online Access:http://www.mdpi.com/1424-8247/3/8/2592/

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