Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma

Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma

Abstract Background Glioblastoma multiforme (GBM) is a devastating disease that lacks effective drugs for targeted therapy. Previously, we found that the third-generation epidermal growth factor receptor (EGFR) inhibitor AZD-9291 persistently blocked the activation of the ERK pathway but had no inhi...

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Bibliographic Details
Main Authors: Tongxuan Guo, Changyong Wu, Junhao Zhang, Jiefeng Yu, Guoxi Li, Hongyan Jiang, Xu Zhang, Rutong Yu, Xuejiao Liu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Cell Communication and Signaling
Subjects:
Glioblastoma
AZD-9291
GDC-0084
Combination therapy
Synergistic inhibition
Online Access:https://doi.org/10.1186/s12964-023-01400-0

Internet

https://doi.org/10.1186/s12964-023-01400-0

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