Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment

Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment

IntroductionAt least one-third of the identified risk alleles from Genome-Wide Association Studies (GWAS) of Alzheimer’s disease (AD) are involved in lipid metabolism, lipid transport, or direct lipid binding. In fact, a common genetic variant (ε4) in a cholesterol and phospholipid transporter, Apol...

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Bibliographic Details
Main Authors: Jason Mares, Ana Paula Costa, William J. Dartora, Krista M. Wartchow, Artur Lazarian, David A. Bennett, Tal Nuriel, Vilas Menon, Laura Beth J. McIntire
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
lipidomics
lipid metabolism
Alzheimer’s disease
ROSMAP
ApoE
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1419253/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2024.1419253/full

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