Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression

Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression

Abstract Overexpression of histone deacetylases (HDACs) in cancer commonly causes resistance to genotoxic-based therapies. Here, we report on the novel mechanism whereby overexpressed class I HDACs increase the resistance of glioblastoma cells to the SN1 methylating agent temozolomide (TMZ). The che...

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Bibliographic Details
Main Authors: Daniela Hanisch, Andrea Krumm, Tamara Diehl, Carla M. Stork, Mario Dejung, Falk Butter, Ella Kim, Walburgis Brenner, Gerhard Fritz, Thomas G. Hofmann, Wynand P. Roos
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04751-7

Internet

https://doi.org/10.1038/s41419-022-04751-7

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