Anticoagulant therapy without bleeding: A novel molybdenum‐based nanodots alleviate lethal coagulation in bacterial sepsis by inhibiting ROS‐facilitated caspase‐11 activation

Anticoagulant therapy without bleeding: A novel molybdenum‐based nanodots alleviate lethal coagulation in bacterial sepsis by inhibiting ROS‐facilitated caspase‐11 activation

Abstract Sepsis is a leading cause of death worldwide. This syndrome is commonly accompanied by overactivation of coagulation, excessive reactive oxygen species (ROS), and inflammatory cytokine storm. Notably, disseminated intravascular coagulation (DIC) accounts for around 40% of sepsis‐associated...

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Bibliographic Details
Main Authors: Chuang Yuan, Qicai Xiao, Qiaohui Chen, Qiong Huang, Kelong Ai, Xinyu Yang
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:SmartMat
Subjects:
caspase‐11
coagulation
gallic acid‐modified Mo‐based polyoxometalate dots
lipopolysaccharide internalization
reactive oxygen species scavenger
sepsis
Online Access:https://doi.org/10.1002/smm2.1264

Internet

https://doi.org/10.1002/smm2.1264

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