Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex

Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex

Human mutations in the cytoplasmic C-terminal domain of Slack sodium-activated potassium (KNa) channels result in childhood epilepsy with severe intellectual disability. Slack currents can be increased by pharmacological activators or by phosphorylation of a Slack C-terminal residue by protein kinas...

Full description

Bibliographic Details
Main Authors: Matthew R. Fleming, Maile R. Brown, Jack Kronengold, Yalan Zhang, David P. Jenkins, Gulia Barcia, Rima Nabbout, Anne E. Bausch, Peter Ruth, Robert Lukowski, Dhasakumar S. Navaratnam, Leonard K. Kaczmarek
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716309263

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716309263

Similar Items