Nucleus accumbens shell neurons’ early sensitivity to cocaine is associated with future increases in drug intake

The striatum, both dorsal and ventral, is strongly implicated in substance use disorder. Chronic consumption of abused substances, such as cocaine, can cause an oversaturation of mesostriatal dopamine, which results in alterations in the firing of striatal neurons. While most preclinical studies of...

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Bibliographic Details
Main Authors: Ashley K. Crawley, Anirudh Sharma, Kevin R. Coffey, Mark O. West, David J. Barker
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Addiction Neuroscience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2772392523000500