Molecular mechanisms underlying the heterogeneous barrier responses of two primary endothelial cell types to sphingosine-1-phosphate

Molecular mechanisms underlying the heterogeneous barrier responses of two primary endothelial cell types to sphingosine-1-phosphate

Sphingosine-1-phosphate (S1P) signals to enhance or destabilize the vascular endothelial barrier depending on the receptor engaged. Here, we investigated the differential barrier effects of S1P on two influential primary endothelial cell (EC) types, human umbilical vein endothelial cells (HUVECs) an...

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Bibliographic Details
Main Authors: Alec T. Salminen, Molly C. McCloskey, S. Danial Ahmad, Samantha S. Romanick, Kaihua Chen, William Houlihan, Michael E. Klaczko, Jonathan Flax, Richard E. Waugh, James L. McGrath
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:European Journal of Cell Biology
Subjects:
Endothelial cell heterogeneity
Sepsis
ARDS
Sphingosine-1-Phosphate
Vascular barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S017193352200036X

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http://www.sciencedirect.com/science/article/pii/S017193352200036X

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