Inhibition of BRD4 Reduces Neutrophil Activation and Adhesion to the Vascular Endothelium Following Ischemia Reperfusion Injury

Inhibition of BRD4 Reduces Neutrophil Activation and Adhesion to the Vascular Endothelium Following Ischemia Reperfusion Injury

Renal ischemia reperfusion injury (IRI) is associated with inflammation, including neutrophil infiltration that exacerbates the initial ischemic insult. The molecular pathways involved are poorly characterized and there is currently no treatment. We performed an in silico analysis demonstrating chan...

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Bibliographic Details
Main Authors: Shelby Reid, Noah Fine, Vikrant K. Bhosle, Joyce Zhou, Rohan John, Michael Glogauer, Lisa A. Robinson, James W. Scholey
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
ischemia-reperfusion
NFκB
BRD4
inflammation
neutrophils
tubule injury
Online Access:https://www.mdpi.com/1422-0067/21/24/9620

Internet

https://www.mdpi.com/1422-0067/21/24/9620

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