Identification of pharmacokinetic markers for safflower injection using a combination of system pharmacology, multicomponent pharmacokinetics, and quantitative proteomics study

Identification of pharmacokinetic markers for safflower injection using a combination of system pharmacology, multicomponent pharmacokinetics, and quantitative proteomics study

Safflower injection (SI), a water-extract preparation from safflower (Carthamus tinctorius L.), has been widely used for the treatment of cardio-cerebrovascular diseases. This work aims to develop an approach for identifying PK markers of cardiovascular herbal medicines using SI as a case study. Fir...

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Bibliographic Details
Main Authors: Peiying Shi, Yijun Ruan, Chenhui Zhong, Linglin Teng, Liyuan Ke, Hong Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
PK marker
safflower injection
multicomponent pharmacokinetics
system pharmacology
quantitative proteomics
hydroxysafflor yellow A
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1062026/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1062026/full

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