The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial hypertension but are not suitable for exogenous administration owing to a lack of...

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Bibliographic Details
Main Authors: Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E. Kuc, Thomas L. Williams, Christopher M. Fitzpatrick, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
apelin
bias
cardiovascular
in vivo
apoptosis
pulmonary artery endothelial cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.588669/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.588669/full

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