Phosphorylation of S6RP in peritubular capillaries of kidney grafts and circulating HLA donor-specific antibodies

Phosphorylation of S6RP in peritubular capillaries of kidney grafts and circulating HLA donor-specific antibodies

Antibody-mediated rejection (ABMR) caused by donor-specific HLA-antibodies (DSA) is a mediator of allograft loss after kidney transplantation (KT). DSA can activate microvascular endothelium damage through the mTOR pathway. In this study we assessed the mTOR pathway activation by DSA in KT with ABMR...

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Bibliographic Details
Main Authors: Dalia Raïch-Regué, Javier Gimeno, Laura Llinàs-Mallol, Silvia Menéndez, David Benito, Dolores Redondo, M. José Pérez-Sáez, Marta Riera, Elaine F. Reed, Julio Pascual, Marta Crespo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Medicine
Subjects:
transplantation—kidney
donor specific antibodies
mammalian target of rapamycin (mTOR)
phosphorylation
peritubular capillaries
ribosomal protein S6 (S6RP)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.988080/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.988080/full

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