Synthesis of Reusable Silica Nanosphere-Supported Pt(IV) Complex for Formation of Disulfide Bonds in Peptides

Synthesis of Reusable Silica Nanosphere-Supported Pt(IV) Complex for Formation of Disulfide Bonds in Peptides

Some peptide-based drugs, including oxytocin, vasopressin, ziconotide, pramlintide, nesiritide, and octreotide, contain one intramolecular disulfide bond. A novel and reusable monodispersed silica nanosphere-supported Pt(IV) complex (SiO2@TPEA@Pt(IV)); TPEA: N-[3-(trimethoxysilyl)propyl]ethylenediam...

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Bibliographic Details
Main Authors: Xiaonan Hou, Xiaowei Zhao, Yamei Zhang, Aiying Han, Shuying Huo, Shigang Shen
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Molecules
Subjects:
monodisperse silica nanospheres
supported platinum(IV) complex
peptide
intramolecular disulfide
reusability
Online Access:http://www.mdpi.com/1420-3049/22/2/338

Internet

http://www.mdpi.com/1420-3049/22/2/338

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