Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation

Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation

Abstract Background DNA methylation (DNAm) is a critical regulator of both development and cellular identity and shows unique patterns in neurons. To better characterize maturational changes in DNAm patterns in these cells, we profile the DNAm landscape at single-base resolution across the first two...

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Bibliographic Details
Main Authors: Amanda J. Price, Leonardo Collado-Torres, Nikolay A. Ivanov, Wei Xia, Emily E. Burke, Joo Heon Shin, Ran Tao, Liang Ma, Yankai Jia, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger, Andrew E. Jaffe
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Genome Biology
Subjects:
DNA methylation
Neurodevelopment
Gene expression
Non-CpG methylation
Online Access:http://link.springer.com/article/10.1186/s13059-019-1805-1

Internet

http://link.springer.com/article/10.1186/s13059-019-1805-1

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