An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors

An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors

ABSTRACTConflicting evidence exists on the association between consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic worsening of inflammatory bowel disease (IBD). We hypothesized that the heterogeneous prevalence of pathobionts [e.g., adherent-invasive Escherichia coli (AIEC...

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Bibliographic Details
Main Authors: Raminder Singh, Valerio Rossini, Stephen R. Stockdale, Gonzalo Saiz-Gonzalo, Naomi Hanrahan, Tanya D’ Souza, Adam Clooney, Lorraine A. Draper, Colin Hill, Ken Nally, Fergus Shanahan, Stefan Andersson-Engels, Silvia Melgar
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
AIEC
piroxicam
inflammatory bowel disease
cell death
IL10−/− mice
inflammasome
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2163838

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2022.2163838

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