A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge

A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge

Abstract Background Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in children. Until now, no cure nor mucosal vaccine existed for EV-A71 and EV...

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Bibliographic Details
Main Authors: Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan, Bor-Luen Chiang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Biomedical Science
Subjects:
Acute flaccid myelitis
Acute flaccid paralysis
Adjuvant
Enterovirus A71
Enterovirus D68
Intranasal
Online Access:https://doi.org/10.1186/s12929-023-00987-3

Internet

https://doi.org/10.1186/s12929-023-00987-3

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