Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose

The purpose of this study was to develop an extended-release (ER) matrix tablet that shows robust dissolution properties able to account for the variability of pH and mechanical stress in the GI tract using a combination of enteric polymer and hydrophilic polymer. Hypromellose acetate succinate (HPM...

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Bibliographic Details
Main Authors: Sachiko Fukui, Hideki Yano, Shuichi Yada, Tsuyoshi Mikkaichi, Hidemi Minami
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616302094