Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase

Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase

The human immunodeficiency virus type-1 Reverse Transcriptase (HIV-1 RT) plays a pivotal role in essential viral replication and is the main target for antiviral therapy. The anti-HIV-1 RT drugs address resistance-associated mutations. This research focused on isolating the potential specific DNA ap...

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Bibliographic Details
Main Authors: Siriluk Ratanabunyong, Supaphorn Seetaha, Supa Hannongbua, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Atchara Paemanee, Kiattawee Choowongkomon
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
HIV-1 RT
DNA aptamer
K103N/Y181C double mutant
gold nanoparticles
SPR
NMR
Online Access:https://www.mdpi.com/1420-3049/27/1/285

Internet

https://www.mdpi.com/1420-3049/27/1/285

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