The transcription factor HIF2α partakes in the differentiation block of acute myeloid leukemia

The transcription factor HIF2α partakes in the differentiation block of acute myeloid leukemia

Abstract One of the defining features of acute myeloid leukemia (AML) is an arrest of myeloid differentiation whose molecular determinants are still poorly defined. Pharmacological removal of the differentiation block contributes to the cure of acute promyelocytic leukemia (APL) in the absence of cy...

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Bibliographic Details
Main Authors: Daniela Magliulo, Matilde Simoni, Carolina Caserta, Cristina Fracassi, Serena Belluschi, Kety Giannetti, Raffaella Pini, Ettore Zapparoli, Stefano Beretta, Martina Uggè, Eleonora Draghi, Federico Rossari, Nadia Coltella, Cristina Tresoldi, Marco J Morelli, Raffaella Di Micco, Bernhard Gentner, Luca Vago, Rosa Bernardi
Format: Article
Language:English
Published: Springer Nature 2023-11-01
Series:EMBO Molecular Medicine
Subjects:
AML
ATRA
differentiation therapy
HIF2α
Online Access:https://doi.org/10.15252/emmm.202317810

Internet

https://doi.org/10.15252/emmm.202317810

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