Engineered cord blood megakaryocytes evade killing by allogeneic T-cells for refractory thrombocytopenia

Engineered cord blood megakaryocytes evade killing by allogeneic T-cells for refractory thrombocytopenia

The current global platelet supply is often insufficient to meet all the transfusion needs of patients, in particular for those with alloimmune thrombocytopenia. To address this issue, we have developed a strategy employing a combination of approaches to achieve more efficient production of function...

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Bibliographic Details
Main Authors: Bijender Kumar, Vahid Afshar-Kharghan, Mayela Mendt, Robert Sackstein, Mark R. Tanner, Uday Popat, Jeremy Ramdial, May Daher, Juan Jimenez, Rafet Basar, Luciana Melo Garcia, Mayra Shanley, Mecit Kaplan, Xinhai Wan, Vandana Nandivada, Francia Reyes Silva, Vernikka Woods, April Gilbert, Ricardo Gonzalez-Delgado, Sunil Acharya, Paul Lin, Hind Rafei, Pinaki Prosad Banerjee, Elizabeth J. Shpall
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
megakaryocyte
rho-associated coiled coil-containing protein kinase
platelet
cord blood
beta2 microglobin
thrombocytopaenia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1018047/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1018047/full

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