Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation

Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation

Post-translational modifications can lead to a break in immune tolerance in autoimmune diseases such as type 1 diabetes (T1D). Deamidation, the conversion of glutamine to glutamic acid by transglutaminase (TGM) enzymes, is a post-translational modification of interest, with deamidated peptides being...

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Bibliographic Details
Main Authors: Aїsha Callebaut, Ylke Bruggeman, Cloé Zamit, Fernanda Marques Câmara Sodré, Magali Irla, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
diabetes
neoepitopes
deamidation
post-translational modification
NOD mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.908248/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.908248/full

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