Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L

Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L

Objective: In addition to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker region aswell. Phosphorylation of Smad2 linker region (Smad2L) promotes the expression of plasminogen activator inhibitor type1 (PAI-1) which leads to cardiovascular disorders such as atheros...

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Bibliographic Details
Main Authors: hossein babaahmadi rezaei, alireza kheirolah, Faezeh Seif
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2022-08-01
Series:Cell Journal
Subjects:
atherosclerosis
rock
smad2
transactivation
Online Access:https://www.celljournal.org/article_253330_c2d6823710743cbe2c230eabdb8a619a.pdf

Internet

https://www.celljournal.org/article_253330_c2d6823710743cbe2c230eabdb8a619a.pdf

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