Cardiomyocyte-Specific Deletion of Orai1 Reveals Its Protective Role in Angiotensin-II-Induced Pathological Cardiac Remodeling

Cardiomyocyte-Specific Deletion of Orai1 Reveals Its Protective Role in Angiotensin-II-Induced Pathological Cardiac Remodeling

Pathological cardiac remodeling correlates with chronic neurohumoral stimulation and abnormal Ca<sup>2+</sup> signaling in cardiomyocytes. Store-operated calcium entry (SOCE) has been described in adult and neonatal murine cardiomyocytes, and Orai1 proteins act as crucial ion-conducting...

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Bibliographic Details
Main Authors: Sebastian Segin, Michael Berlin, Christin Richter, Rebekka Medert, Veit Flockerzi, Paul Worley, Marc Freichel, Juan E. Camacho Londoño
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
calcium
cardiac remodeling
cardiac function
Orai1 proteins
neurohumoral stimulus
Online Access:https://www.mdpi.com/2073-4409/9/5/1092

Internet

https://www.mdpi.com/2073-4409/9/5/1092

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